Ian N Bruce Selected Research

anifrolumab

1/2023	A Randomized, Placebo-Controlled Phase III Extension Trial of the Long-Term Safety and Tolerability of Anifrolumab in Active Systemic Lupus Erythematosus.
1/2023	Letter in reply: indirect treatment comparison of anifrolumab efficacy versus belimumab in adults with systemic lupus erythematosus.
1/2023	Time to onset of clinical response to anifrolumab in patients with SLE: pooled data from the phase III TULIP-1 and TULIP-2 trials.
4/2022	Efficacy of anifrolumab across organ domains in patients with moderate-to-severe systemic lupus erythematosus: a post-hoc analysis of pooled data from the TULIP-1 and TULIP-2 trials.
1/2022	Anifrolumab efficacy and safety by type I interferon gene signature and clinical subgroups in patients with SLE: post hoc analysis of pooled data from two phase III trials.
1/2022	Concordance and discordance in SLE clinical trial outcome measures: analysis of three anifrolumab phase 2/3 trials.
1/2022	Indirect treatment comparison of anifrolumab efficacy versus belimumab in adults with systemic lupus erythematosus.
2/2021	Pharmacokinetics, pharmacodynamics, and safety of subcutaneous anifrolumab in patients with systemic lupus erythematosus, active skin disease, and high type I interferon gene signature: a multicentre, randomised, double-blind, placebo-controlled, phase 2 study.
1/2020	Trial of Anifrolumab in Active Systemic Lupus Erythematosus.
12/2019	Type I interferon inhibitor anifrolumab in active systemic lupus erythematosus (TULIP-1): a randomised, controlled, phase 3 trial.

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Ian N Bruce Research Topics

Disease

58	Systemic Lupus Erythematosus (Libman-Sacks Disease) 05/2024 - 02/2003
12	Inflammation (Inflammations) 01/2023 - 08/2005
11	Lupus Nephritis 10/2023 - 08/2012
10	Rheumatoid Arthritis 01/2023 - 01/2005
7	Arthritis (Polyarthritis) 01/2022 - 06/2007
6	Infections 05/2023 - 03/2002
6	Atherosclerosis 07/2015 - 02/2003
5	Vasculitis (Vasculitides) 05/2023 - 04/2012
5	Hypertension (High Blood Pressure) 10/2021 - 02/2003
5	Cardiovascular Diseases (Cardiovascular Disease) 04/2014 - 08/2005
5	Psoriatic Arthritis 04/2012 - 06/2007
5	Psoriasis (Pustulosis Palmaris et Plantaris) 04/2012 - 06/2007
4	Cutaneous Lupus Erythematosus 01/2023 - 12/2019
4	Fatigue 12/2021 - 03/2002
4	Insulin Resistance 10/2021 - 01/2006
4	Rheumatic Diseases (Rheumatism) 07/2021 - 03/2015
4	Necrosis 01/2017 - 08/2008
3	Skin Diseases (Skin Disease) 02/2021 - 04/2012
3	Vitamin D Deficiency 01/2017 - 03/2012
3	Joint Diseases (Joint Disease) 04/2012 - 06/2007
2	Headache (Headaches) 12/2021 - 11/2013
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 10/2021 - 01/2006
2	COVID-19 06/2021 - 12/2020
2	Herpes Zoster 02/2021 - 01/2020
2	Arthralgia (Joint Pain) 07/2019 - 03/2002
2	Connective Tissue Diseases (Connective Tissue Disease) 01/2017 - 01/2016
2	Proteinuria 12/2016 - 01/2016
2	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 03/2015 - 04/2012
2	Coronary Disease (Coronary Heart Disease) 02/2010 - 08/2008
1	Ataxia (Dyssynergia) 04/2024
1	Cranial Nerve Diseases (Cranial Nerve Disorders) 04/2024
1	Vascular Calcification 02/2024
1	Chronic Limb-Threatening Ischemia 02/2024
1	Body Weight (Weight, Body) 10/2023
1	Takayasu Arteritis (Arteritis, Takayasu's) 05/2023
1	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2023
1	Atopic Dermatitis (Atopic Eczema) 01/2023
1	Asymptomatic Infections 01/2023
1	Alopecia Areata 01/2023
1	Seizures (Absence Seizure) 01/2023
1	Serositis 11/2022

Drug/Important Bio-Agent (IBA)

12	AutoantibodiesIBA 04/2024 - 03/2002
11	GlucocorticoidsIBA 05/2023 - 01/2020
10	Rituximab (Mabthera)FDA Link 12/2023 - 05/2010
10	anifrolumabIBA 01/2023 - 12/2019
7	belimumabIBA 10/2023 - 01/2019
6	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 12/2023 - 08/2008
6	Biomarkers (Surrogate Marker)IBA 01/2023 - 08/2008
6	Vitamin D FDA LinkGeneric 10/2021 - 03/2012
6	Antirheumatic Agents (DMARD)IBA 06/2021 - 01/2005
6	Interferon Type IIBA 02/2021 - 12/2016
5	InterferonsIBA 01/2023 - 12/2019
5	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 08/2012
4	AntibodiesIBA 04/2024 - 10/2005
4	Proteins (Proteins, Gene)FDA Link 04/2024 - 01/2021
4	Mycophenolic Acid (Cellcept)FDA LinkGeneric 09/2023 - 01/2016
4	Adrenal Cortex Hormones (Corticosteroids)IBA 12/2019 - 08/2005
3	Monoclonal AntibodiesIBA 12/2023 - 01/2020
3	Oxygen (Dioxygen)IBA 01/2023 - 09/2013
3	baricitinibIBA 01/2023 - 01/2018
3	B-Cell Activating FactorIBA 11/2022 - 01/2019
3	Antinuclear AntibodiesIBA 01/2022 - 08/2012
3	LipidsIBA 01/2022 - 08/2008
3	C-Reactive ProteinIBA 01/2019 - 03/2013
3	CytokinesIBA 01/2018 - 05/2014
3	SteroidsIBA 09/2015 - 10/2005
3	Insulin (Novolin)FDA Link 03/2012 - 01/2006
2	oxidized low density lipoproteinIBA 02/2024 - 01/2006
2	LDL Lipoproteins (beta Lipoproteins)IBA 02/2024 - 01/2006
2	Prednisone (Sone)FDA LinkGeneric 12/2023 - 11/2022
2	Anti-Bacterial Agents (Antibiotics)IBA 05/2023 - 10/2018
2	tocilizumab (atlizumab)FDA Link 05/2023 - 06/2012
2	Prednisolone (Predate)FDA LinkGeneric 05/2023 - 11/2021
2	Immunosuppressive Agents (Immunosuppressants)IBA 01/2023 - 11/2022
2	Antiphospholipid AntibodiesIBA 01/2023 - 08/2005
2	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2019
2	Interleukin-6 (Interleukin 6)IBA 12/2021 - 01/2019
2	Antimalarials (Antimalarial Agents)IBA 11/2021 - 11/2013
2	HDL LipoproteinsIBA 10/2021 - 08/2011
2	hydroxide ionIBA 10/2021 - 03/2012
2	Abatacept (Orencia)FDA Link 07/2019 - 06/2012
2	Interferon-alpha (Interferon Alfa)IBA 01/2019 - 05/2014
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2019 - 10/2005
2	Lupus Coagulation Inhibitor (Lupus Anticoagulant)IBA 10/2018 - 01/2016
2	Triglycerides (Triacylglycerol)IBA 01/2018 - 01/2011
2	beta-cyclodextrin tetradecasulfate (CTDS)IBA 01/2017 - 01/2016
2	Protein Isoforms (Isoforms)IBA 09/2013 - 05/2008
2	Glucose (Dextrose)FDA LinkGeneric 08/2011 - 01/2006
1	KinesinsIBA 04/2024
1	GlycerophosphatesIBA 02/2024
1	OsteoprotegerinIBA 02/2024
1	OsteocalcinIBA 02/2024
1	voclosporinIBA 10/2023
1	Retinaldehyde (Retinal)IBA 10/2023
1	Tacrolimus (Prograf)FDA LinkGeneric 10/2023
1	Azathioprine (Imuran)FDA LinkGeneric 01/2023
1	Janus Kinase 1IBA 01/2023
1	anti-dsDNA autoantibodyIBA 11/2022

Therapy/Procedure

26	Therapeutics 05/2024 - 02/2003
3	Biological Therapy 01/2018 - 05/2010